Pain is one of the most unpleasant feelings of human body. Nervous excitability, if abnormally increased, leads to various disorders. Medicines are available to relieve such impairments. Neurontin is a drug that was initially designed to mimic the action of GABA, a naturally found neurotransmitter inhibitor. Neurontin is an effective drug that provides cure for epileptic syndrome and pain.
Neurontin, chemically called as Gabapentin, was expected to neutralize the nerve impulse at the point of its transmission which is the normal action of GABA, but it differed in its mechanism of action. Although its role in the neutralization of nerve action potential was quite positive, it acted in another way by effecting calcium channels. GABA is natural inhibitors of action potentials that regulate the chloride and potassium channels in a way to neutralize the negativity of the action potential across the neuronal cellular membrane thus causing hyper polarization. Neurontin or Gabapentin affected the calcium channels instead and inhibited the release of the neurotransmitters thereby reducing the excitability and countermanding the increase in the excitatory levels in epilepsy.
The medicine is FDA approved in the treatment of partial seizures and post therapeutic neuralgia. It reduces the chances of other neuropathies and pain of nerves. Post therapeutic pain is not caused by the stimulation of noci-receptors, known for pain reception. Instead it is caused by changes in the nervous cell structure itself. Since it is a nervous function inhibitor, it is also known for its effective treatment for addiction of various drugs including cocaine and alcohol. It helps to minimize the withdrawal symptoms that ensue at the treatment of alcoholism and other sort of addiction. Its combination with flumazenil is an authorized medication against addiction and withdrawal symptoms.
Nystagamus characterized by abnormal eye movements is also cured by Neurontin. It can also suppress the adverse effects of Major depression apart from treating neuralgia. Complex regional pain syndrome is also treated by Neurontin effectively. Opiate withdrawal symptoms and post menopausal hot flashes are also effectively suppressed.
Gabapentin is administered orally at a dosage of 1200mg a bedtime for one to two months. The drug use should not be discontinued after its regular use as it may also cause withdrawal symptoms muck like those of cocaine and alcohol. Slow and gradual fall in the dosage is recommended to avoid withdrawal symptoms.
Some of the side effects of the medicine include drowsiness, peripheral edema. Children of age 10 were observed to be susceptible to hostility, mood swings and hyperactivity. It may cause toxicity of liver and kidney. Overdosage of the drug might lead to blurred vision, slurred speech or even coma.
If you are an unfortunate person suffering from epilepsy and often encounter neuralgic pain as a cause of your suffering, Neurontin is the right choice for you to buy. Orderable in a most convenient way from our online pharmacy, the medicine is delivered to your door steps upon a single click of yours on our website. Manufactured by Pfizer, we maintain the highest quality of Neurontin and in an affordable way.
Serum phenytoin levels can rise if progabide is used concurrently
. A reduction in the dosage of phenytoin may be required. A rise in serum phenobarbitone levels has been seen. Changes in the serum levels of other anticonvulsants (carbamazepine, sodium valproate, clonazepam) caused by progabide and their effects on serum progabide levels appear to be small.